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into the nucleus of a cell. The packaging further provides a regulatory layer for DNA accessibility and therefore all DNA-dependent processes, such as transcription, DNA repair or replication. ATP-dependent
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in the LE disease process would facilitate early diagnosis and reveal targets for early intervention, changing the current paradigm from ‘long-term management of chronic inflammation’ to ‘prevention
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that BAF complexes are also actively implicated in genome stability processes, especially those that involve DNA double-strand breaks (DSBs), in ways that are also likely independent from their chromatin
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., cellular processes like hydrolysis, oxidation, alkylation, impediment to replication fork etc., can also damage DNA endogenously. Cells have evolved multiple DNA repair pathways to deal with these DNA